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doi: 10.15835/nbha46110992 97 Villamarin-RaadD

J Biol Chem 276:1893418940

Total glutathione measured in HEK-293T cells overexpressing vector, WT hCHAC1, E115A CHAC1 mutant, or E115Q CHAC1 mutant

Under normal conditions, thyroid hormone production is controlled by the hypothalamic-pituitary-thyroid (HPT) axis via a negative feedback loop [4]

Key pro-inflammatory mediatorssuch as IL6, TNF, and COX2activate survival pathways (e.g., JAK/STAT, NFB) promoting proliferation, angiogenesis, and immune evasion